Get Anticancer Drug Development PDF

By Bruce C. Baguley (Author), David J. Kerr (Author)

ISBN-10: 0080490441

ISBN-13: 9780080490441

ISBN-10: 0120726513

ISBN-13: 9780120726516

Right here in one resource is an entire spectrum of rules at the improvement of recent anticancer medicinal drugs. Containing concise reports of multidisciplinary fields of study, this e-book deals a wealth of principles on present and destiny molecular objectives for drug layout, together with sign transduction, the mobilephone department cycle, and programmed telephone demise. targeted descriptions of assets for brand new medicinal drugs and techniques for checking out and scientific trial layout also are supplied. KEY FEATURES:* One paintings that may be consulted for all elements of anticancer drug improvement* Concise reports of analysis fields, mixed with sensible medical element, written by way of across the world revered specialists* A wealth of rules on present and destiny molecular goals for drug layout, together with sign transduction, the mobilephone department cycle, and programmed telephone loss of life * certain descriptions of the assets of recent anticancer medicines, together with combinatorial chemistry, phage demonstrate, and average items* dialogue of ways new medicines might be demonstrated in preclinical structures, together with the most recent know-how of robot assay platforms, mobilephone tradition, and experimental animal ideas* enormous quantities of references that permit the reader to entry appropriate medical and clinical literature* transparent illustrations, a few in colour, that offer either figuring out of the sphere and fabric for instructing

Show description

Read or Download Anticancer Drug Development PDF

Similar oncology books

National Research Council, Institute of Medicine, Patricia's From Cancer Patient to Cancer Survivor - Lost in Transition: PDF

This record of the court cases of a symposium held at the side of the discharge of the IOM record, From melanoma sufferer to melanoma Survivor: misplaced in Transition, represents an attempt at the a part of the yankee Society of scientific Oncology (ASCO), the nationwide Coalition for melanoma Survivorship (NCCS), and the Institute of medication (IOM) to extra disseminate the findings and proposals of the IOM document and to take your next step towards implementation of these techniques.

Download e-book for iPad: Melanoma - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications

This can be a 3-in-1 reference e-book. It provides a whole clinical dictionary protecting hundreds of thousands of phrases and expressions on the subject of cancer. It additionally offers broad lists of bibliographic citations. ultimately, it offers details to clients on the right way to replace their wisdom utilizing a number of net assets.

Download PDF by Stephen J. Wetmore, James Y. Suen (auth.), Gregory T. Wolf: Head and Neck Oncology

The place do you start to seem for a contemporary, authoritative article at the diag­ nosis or administration of a selected malignancy? The few basic oncology textbooks are as a rule old-fashioned. unmarried papers in really expert journals are informative yet seldom entire; those are extra usually initial experiences on a truly constrained variety of sufferers.

Additional info for Anticancer Drug Development

Sample text

1999). Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene 18, 3673–3681. Kastan, M. , and Craig, R. W. (1991). Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51, 6304–6311. , Hiebert, S. , Ewen, M. , and Sherr, C. J. (1993). Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7, 331–342. , and Sausville, E. (1992). Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275.

Cogswell, J. , and Lee, J. M. (1999). p53 regulates a G2 checkpoint through cyclin B1. Proc. Natl. Acad. Sci. USA 96, 2147–2152. , Marin, M. , Phillips, A. , Seelan, R. , Smith, D. , Flores, E. , Tsai, K. , Vousden, K. , and Kaelin, W. G. (2000). Role of the p53 homologue p73 in E2F-1 apoptosis. Nature 407, 645–648. , and Maller, J. L. (1993). Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol. Biol. Cell. 4, 1337–1350. , and Yang, L. Y. (1999).

Biochem. J. 296, 297–301. , and Bartkova, J. (1999). Perspective: defects in cell cycle control and cancer. J. Pathol. 187, 95–99. , and Bartek, J. (1997). Aberrations of the G1- and G1/S-regulating genes in human cancer. Prog. Cell Cycle Res. 3, 211–220. Bible, K. , Bible, R. , Kottke, T. , Svingen, P. , Pang, Y. , and Kaufmann, S. H. (2000). Flavopiridol binds to duplex DNA. Cancer Res. 60, 2419–2428. Bible, K. , and Kaufmann, S. H. (1997). Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration.

Download PDF sample

Anticancer Drug Development by Bruce C. Baguley (Author), David J. Kerr (Author)


by Jason
4.1

Rated 4.58 of 5 – based on 10 votes